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1

Immobilization of Natural Products on Glass Slides by Using a Photoaffinity Reaction and the Detection of Protein–Small-Molecule Interactions

Naoki Kanoh, Saori Kumashiro, Siro Simizu, Yasumitsu Kondoh, Satoru Hatakeyama, Hideo Tashiro, Hiroyuki Osada

Journal:

Angewandte Chemie International Edition

Year:

2003

Language:

english

File:

PDF, 209 KB

english, 2003

2

Therapeutic activity of plant-derived alkaloid conophylline on metabolic syndrome and neurodegenerative disease models

Umezawa, Kazuo, Kojima, Itaru, Simizu, Siro, Lin, Yinzhi, Fukatsu, Hitomi, Koide, Naoki, Nakade, Yukiomi, Yoneda, Masashi

Journal:

Year:

2017

Language:

english

File:

PDF, 852 KB

english, 2017

3

Total Synthesis of Natural Products Using Intramolecular NozakiâHiyamaâTakaiâKishi Reactions

Takao, Ken-ichi, Ogura, Akihiro, Yoshida, Keisuke, Simizu, Siro

Journal:

Year:

2020

File:

PDF, 1.16 MB

2020

4

Immobilization of Natural Products on Glass Slides by Using a Photoaffinity Reaction and the Detection of Protein–Small-Molecule Interactions

Naoki Kanoh, Saori Kumashiro, Siro Simizu, Yasumitsu Kondoh, Satoru Hatakeyama, Hideo Tashiro, Hiroyuki Osada

Journal:

Angewandte Chemie

Year:

2003

Language:

english

File:

PDF, 208 KB

english, 2003

5

Photo-Cross-Linked Small-Molecule Affinity Matrix for Facilitating Forward and Reverse Chemical Genetics

Naoki Kanoh, Kaori Honda, Siro Simizu, Makoto Muroi, Hiroyuki Osada

Journal:

Angewandte Chemie

Year:

2005

Language:

english

File:

PDF, 459 KB

english, 2005

6

Photo-Cross-Linked Small-Molecule Affinity Matrix for Facilitating Forward and Reverse Chemical Genetics

Naoki Kanoh, Kaori Honda, Siro Simizu, Makoto Muroi, Hiroyuki Osada

Journal:

Angewandte Chemie

Year:

2005

File:

PDF, 173 KB

2005

7

Photo-Cross-Linked Small-Molecule Affinity Matrix for Facilitating Forward and Reverse Chemical Genetics

Naoki Kanoh, Kaori Honda, Siro Simizu, Makoto Muroi, Hiroyuki Osada

Journal:

Angewandte Chemie International Edition

Year:

2005

Language:

english

File:

PDF, 459 KB

english, 2005

8

Photo-Cross-Linked Small-Molecule Affinity Matrix for Facilitating Forward and Reverse Chemical Genetics

Naoki Kanoh, Kaori Honda, Siro Simizu, Makoto Muroi, Hiroyuki Osada

Journal:

Angewandte Chemie International Edition

Year:

2005

File:

PDF, 173 KB

2005

9

On-Chip Fragment-Based Approach for Discovery of High-Affinity Bivalent Inhibitors

Isao Miyazaki, Siro Simizu, Keisuke Ishida, Hiroyuki Osada

Journal:

Year:

2009

Language:

english

File:

PDF, 716 KB

english, 2009

10

Structure–Affinity Relationship Study of Bleomycins and Shble Protein by Use of a Chemical Array

Isao Miyazaki, Hideo Okumura, Siro Simizu, Yoshikazu Takahashi, Naoki Kanoh , Yasuhiko Muraoka, Yoshiaki Nonomura, Hiroyuki Osada

Journal:

Year:

2009

Language:

english

File:

PDF, 547 KB

english, 2009

11

Development of a Vaccinia H1-Related (VHR) Phosphatase Inhibitor with a Nonacidic Phosphate-Mimicking Core Structure

Dr. Go Hirai, Dr. Ayako Tsuchiya, Yusuke Koyama, Dr. Yuko Otani, Kana Oonuma, Dr. Kosuke Dodo, Dr. Siro Simizu, Dr. Hiroyuki Osada, Dr. Mikiko Sodeoka

Journal:

Year:

2011

Language:

english

File:

PDF, 682 KB

english, 2011

12

Rational design and synthesis of novel heparan sulfate mimetic compounds as antiadhesive agents

Keisuke Ishida, Siro Simizu, Takayuki Teruya, Michal K. Wierzba, Hiroyuki Osada

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 434 KB

english, 2004

13

Novel Heparan Sulfate Mimetic Compounds as Antitumor Agents

Keisuke Ishida, Michal K Wierzba, Takayuki Teruya, Siro Simizu, Hiroyuki Osada

Journal:

Chemistry & Biology

Year:

2004

Language:

english

File:

PDF, 775 KB

english, 2004

14

Inhibition of Cyclin D1 Expression and Induction of Apoptosis by Inostamycin in Small Cell Lung Carcinoma Cells

Masaya Imoto, Keiko Tanabe, Siro Simizu, Etsu Tashiro, Minoru Takada, Kazuo Umezawa

Journal:

Year:

1998

Language:

english

File:

PDF, 416 KB

english, 1998

15

Potentiation of Paclitaxel Cytotoxicity by Inostamycin in Human Small Cell Lung Carcinoma, Ms-1 Cells

Siro Simizu, Keiko Tanabe, Etsu Tashiro, Minoru Takada, Kazuo Umezawa, Masaya Imoto

Journal:

Year:

1998

Language:

english

File:

PDF, 445 KB

english, 1998

16

Caspase-3 Activation Is Not Responsible for Vinblastine-induced Bcl-2 Phosphorylation and G2/M Arrest in Human Small Cell Lung Carcinoma Ms-1 Cells

Etsu Tashiro, Siro Simizu, Minoru Takada, Kazuo Umezawa, Masaya Imoto

Journal:

Year:

1998

Language:

english

File:

PDF, 594 KB

english, 1998

17

Bcl-2 Inhibits Calcineurin-mediated Fas Ligand Expression in Antitumor Drug-treated Baby Hamster Kidney Cells

Siro Simizu, Futoshi Shibasaki, Hiroyuki Osada

Journal:

Year:

2000

Language:

english

File:

PDF, 146 KB

english, 2000

18

Heparanase as a molecular target of cancer chemotherapy

Siro Simizu, Keisuke Ishida, Hiroyuki Osada

Journal:

Year:

2004

Language:

english

File:

PDF, 404 KB

english, 2004

19

Dephosphorylation of Bcl-2 by protein phosphatase 2A results in apoptosis resistance

Siro Simizu, Yuki Tamura, Hiroyuki Osada

Journal:

Year:

2004

Language:

english

File:

PDF, 386 KB

english, 2004

20

10.1038/35041102

Osada, Hiroyuki, Simizu, Siro

Journal:

Nature Cell Biology

Year:

2000

Language:

english

File:

PDF, 162 KB

english, 2000

21

A cell-based screening to detect inhibitors of BRAF signaling pathway

Asami, Yukihiro, Mori, Mihoko, Koshino, Hiroyuki, Sekiyama, Yasuyo, Teruya, Takayuki, Simizu, Siro, Usui, Takeo, Osada, Hiroyuki

Journal:

The Journal of Antibiotics

Year:

2009

Language:

english

File:

PDF, 147 KB

english, 2009

22

A small-molecule inhibitor shows that pirin regulates migration of melanoma cells

Miyazaki, Isao, Simizu, Siro, Okumura, Hideo, Takagi, Satoshi, Osada, Hiroyuki

Journal:

Nature Chemical Biology

Year:

2010

Language:

english

File:

PDF, 802 KB

english, 2010

23

Photo-Cross-Linked Small-Molecule Microarrays as Chemical Genomic Tools for Dissecting Protein–Ligand Interactions

Naoki Kanoh, Aya Asami, Makoto Kawatani, Kaori Honda, Saori Kumashiro, Hiroshi Takayama, Siro Simizu, Tomoyuki Amemiya, Yasumitsu Kondoh, Satoru Hatakeyama, Keiko Tsuganezawa, Rei Utata, Akiko Tanaka,

Journal:

Chemistry – An Asian Journal

Year:

2006

Language:

english

File:

PDF, 579 KB

english, 2006

24

Suppression of cellular invasion by glybenclamide through inhibited secretion of platelet-derived growth factor in ovarian clear cell carcinoma ES-2 cells

Tamami Yasukagawa, Yuki Niwa, Siro Simizu, Kazuo Umezawa

Journal:

Year:

2012

Language:

english

File:

PDF, 557 KB

english, 2012

25

Requirement of the conserved, hydrophobic C-terminus region for the activation of heparanase

Ngit Shin Lai, Siro Simizu, Daiki Morisaki, Makoto Muroi, Hiroyuki Osada

Journal:

Experimental Cell Research

Year:

2008

Language:

english

File:

PDF, 1.33 MB

english, 2008

26

Protein disulfide isomerase-mediated disulfide bonds regulate the gelatinolytic activity and secretion of matrix metalloproteinase-9

Maola M.G. Khan, Siro Simizu, Takehiro Suzuki, Akiko Masuda, Makoto Kawatani, Makoto Muroi, Naoshi Dohmae, Hiroyuki Osada

Journal:

Experimental Cell Research

Year:

2012

Language:

english

File:

PDF, 1.22 MB

english, 2012

27

Induction of Hydrogen Peroxide Production and Bax Expression by Caspase-3(-Like) Proteases in Tyrosine Kinase Inhibitor-Induced Apoptosis in Human Small Cell Lung Carcinoma Cells

Siro Simizu, Kazuo Umezawa, Minoru Takada, Nadir Arber, Masaya Imoto

Journal:

Experimental Cell Research

Year:

1998

Language:

english

File:

PDF, 366 KB

english, 1998

28

Involvement of Protein Kinase C-Regulated Ceramide Generation in Inostamycin-Induced Apoptosis

Makoto Kawatani, Siro Simizu, Hiroyuki Osada, Minoru Takada, Nadir Arber, Masaya Imoto

Journal:

Experimental Cell Research

Year:

2000

Language:

english

File:

PDF, 300 KB

english, 2000

29

Deamino-hydroxy-phoslactomycin B, a biosynthetic precursor of phoslactomycin, induces myeloid differentiation in HL-60 cells

Siro Simizu, Takayuki Teruya, Toshihiko Nogawa, Harumi Aono, Masashi Ueki, Masakazu Uramoto, Yuichi Kobayashi, Hiroyuki Osada

Journal:

Biochemical and Biophysical Research Communications

Year:

2009

Language:

english

File:

PDF, 572 KB

english, 2009

30

Involvement of autocrine CXCL12/CXCR4 system in the regulation of ovarian carcinoma cell invasion

Nami Miyanishi, Yukino Suzuki, Siro Simizu, Yoshiko Kuwabara, Kouji Banno, Kazuo Umezawa

Journal:

Biochemical and Biophysical Research Communications

Year:

2010

Language:

english

File:

PDF, 393 KB

english, 2010

31

The phosphorylation status and anti-apoptotic activity of Bcl-2 are regulated by ERK and protein phosphatase 2A on the mitochondria

Yuki Tamura, Siro Simizu, Hiroyuki Osada

Journal:

Year:

2004

Language:

english

File:

PDF, 331 KB

english, 2004

32

Phoslactomycin targets cysteine-269 of the protein phosphatase 2A catalytic subunit in cells

Takayuki Teruya, Siro Simizu, Naoki Kanoh, Hiroyuki Osada

Journal:

Year:

2005

Language:

english

File:

PDF, 353 KB

english, 2005

33

Transmembrane domain of Bcl-2 is required for inhibition of ceramide synthesis, but not cytochrome c release in the pathway of inostamycin-induced apoptosis

Makoto Kawatani, Madoka Uchi, Siro Simizu, Hiroyuki Osada, Masaya Imoto

Journal:

Experimental Cell Research

Year:

2003

Language:

english

File:

PDF, 485 KB

english, 2003

34

Expression of heparanase in human tumor cell lines and human head and neck tumors

Siro Simizu, Keisuke Ishida, Michal K. Wierzba, Taka-Aki Sato, Hiroyuki Osada

Journal:

Year:

2003

Language:

english

File:

PDF, 203 KB

english, 2003

35

Involvement of DNA binding domain in the cellular stability and importin affinity of NF-κB component RelB

Takeiri, Masatoshi, Horie, Kana, Takahashi, Daisuke, Watanabe, Mariko, Horie, Ryoichi, Simizu, Siro, Umezawa, Kazuo

Journal:

Organic & Biomolecular Chemistry

Year:

2012

Language:

english

File:

PDF, 1.57 MB

english, 2012

36

Determination of cathepsin V activity and intracellular trafficking by N-glycosylation

Yuki Niwa, Takehiro Suzuki, Naoshi Dohmae, Kazuo Umezawa, Siro Simizu

Journal:

Year:

2012

Language:

english

File:

PDF, 781 KB

english, 2012

37

Migracins A and B, new inhibitors of cancer cell migration, produced by Streptomyces sp.

Arai, Yuhei, Iinuma, Hironobu, Ikeda, Yoko, Igarashi, Masayuki, Hatano, Masaki, Kinoshita, Naoko, Ukaji, Tamami, Simizu, Siro, Umezawa, Kazuo

Journal:

The Journal of Antibiotics

Year:

2013

Language:

english

File:

PDF, 693 KB

english, 2013

38

Inhibition of NO-induced β-cell death by novel NF-κB inhibitor (−)-DHMEQ via activation of Nrf2–ARE pathway

Ogasawara, Akira, Simizu, Siro, Ito, Ayumi, Kawai, Toshihide, Saisho, Yoshifumi, Takei, Izumi, Umezawa, Kazuo

Journal:

Biochemical and Biophysical Research Communications

Year:

2013

Language:

english

File:

PDF, 774 KB

english, 2013

39

Synthesis of (+)-Vinblastine and Its Analogues †

Miyazaki, Tohru, Yokoshima, Satoshi, Simizu, Siro, Osada, Hiroyuki, Tokuyama, Hidetoshi, Fukuyama, Tohru

Journal:

Organic Letters

Year:

2007

Language:

english

File:

PDF, 160 KB

english, 2007

40

Discovery of a Small Molecule PDI Inhibitor That Inhibits Reduction of HIV-1 Envelope Glycoprotein gp120

Khan, Maola M. G., Simizu, Siro, Lai, Ngit Shin, Kawatani, Makoto, Shimizu, Takeshi, Osada, Hiroyuki

Journal:

ACS Chemical Biology

Year:

2011

Language:

english

File:

PDF, 2.53 MB

english, 2011

41

Determination of topological structure of ARL6ip1 in cells: Identification of the essential binding region of ARL6ip1 for conophylline

Kuroda, Masahiro, Funasaki, Shintaro, Saitoh, Tsuyoshi, Sasazawa, Yukiko, Nishiyama, Shigeru, Umezawa, Kazuo, Simizu, Siro

Journal:

Year:

2013

Language:

english

File:

PDF, 647 KB

english, 2013

42

Cleavable Linker for Photo-Cross-Linked Small-Molecule Affinity Matrix

Kanoh, Naoki, Takayama, Hiroshi, Honda, Kaori, Moriya, Takashi, Teruya, Takayuki, Simizu, Siro, Osada, Hiroyuki, Iwabuchi, Yoshiharu

Journal:

Bioconjugate Chemistry

Year:

2010

Language:

english

File:

PDF, 2.19 MB

english, 2010

43

Robust and Systematic Drug Screening Method Using Chemical Arrays and the Protein Library: Identification of Novel Inhibitors of Carbonic Anhydrase II

MIYAZAKI, Isao, SIMIZU, Siro, ICHIMIYA, Harumi, KAWATANI, Makoto, OSADA, Hiroyuki

Journal:

Bioscience Biotechnology and Biochemistry

Year:

2008

Language:

english

File:

PDF, 250 KB

english, 2008

44

Isolation of a novel paxilline analog pyrapaxilline from fungus that inhibits LPS-induced NO production

Matsui, Chino, Ikeda, Yoko, Iinuma, Hironobu, Kushida, Nobuaki, Kunisada, Takao, Simizu, Siro, Umezawa, Kazuo

Journal:

The Journal of Antibiotics

Year:

2014

Language:

english

File:

PDF, 294 KB

english, 2014

45

Induction of Apoptosis by Erbstatin in Mouse Leukemia L1210 Cells

Simizu, Siro, Imoto, Masaya, Umezawa, Kazuo

Journal:

Bioscience Biotechnology and Biochemistry

Year:

1994

Language:

english

File:

PDF, 878 KB

english, 1994

46

Activation of apoptosis by caspase-3-dependent specific RelB cleavage in anticancer agent-treated cancer cells: Involvement of positive feedback mechanism

Kuboki, Mizuki, Ito, Ayumi, Simizu, Siro, Umezawa, Kazuo

Journal:

Biochemical and Biophysical Research Communications

Year:

2015

Language:

english

File:

PDF, 702 KB

english, 2015

47

Pirin regulates epithelial to mesenchymal transition independently of Bcl3-Slug signaling

Komai, Kuniya, Niwa, Yuki, Sasazawa, Yukiko, Simizu, Siro

Journal:

Year:

2015

Language:

english

File:

PDF, 863 KB

english, 2015

48

Conophylline Protects Cells in Cellular Models of Neurodegenerative Diseases by Inducing Mammalian Target of Rapamycin (mTOR)-independent Autophagy

Sasazawa, Yukiko, Sato, Natsumi, Umezawa, Kazuo, Simizu, Siro

Journal:

Journal of Biological Chemistry

Year:

2015

Language:

english

File:

PDF, 2.50 MB

english, 2015

49

Involvement of conserved tryptophan residues for secretion of TIMP‑2

Journal:

Oncology Letters

Year:

2013

Language:

english

File:

PDF, 532 KB

english, 2013

50

Inhibition of MMP-2-Mediated Mast Cell Invasion by NF-κB Inhibitor DHMEQ in Mast Cells

Noma, Naruto, Asagiri, Masataka, Takeiri, Masatoshi, Ohmae, Saori, Takemoto, Kenji, Iwaisako, Keiko, Minato, Nagahiro, Maeda-Yamamoto, Mari, Simizu, Siro, Umezawa, Kazuo

Journal:

International Archives of Allergy and Immunology

Year:

2015

Language:

english

File:

PDF, 332 KB

english, 2015